From systematic reviews to global guidance

In October 2025, BMJ Global Health published an open access supplement, The evidence to establish global guidelines on hand hygiene in community settings. The collection brings together five systematic reviews and forms the evidence base for the World Health Organization (WHO) and UNICEF’s first global Guidelines on Hand Hygiene in Community Settings.

Launched on Global Handwashing Day, the guidelines were announced in a WHO news release, in which WHO states that they translate the best available evidence published in BMJ Global Health into ready-to-adapt actions for governments and health systems worldwide.

Published by leading healthcare knowledge provider, BMJ Group, BMJ Global Health publishes themed supplements in partnership with leading organisations, bringing together peer reviewed research, policy perspectives, and practical insights on key global health topics for a wide audience.

The BMJ Global Health supplement brings together a uniquely broad evidence base on community hand hygiene, spanning behavioural drivers, intervention design, and material and infrastructure requirements. Handwashing with soap and water can reduce the risk of diarrhoeal disease by around 30% and acute respiratory infections by approximately 17%. These two conditions together account for an estimated 740,000 preventable deaths annually.

For Joanna Esteves Mills, global public health consultant and coordinator of the WHO’s guideline development process, the supplement is central to building the evidence base for the new guidelines. Her work on hand hygiene spans WaterAid, the London School of Hygiene and Tropical Medicine and WHO.  

Through her professional experience, Mills describes seeing “many factors that act as a barrier to hand hygiene”, from basic material shortages to “slightly less tangible kind of stickier things around social norms”.

She also notes that “without the really basic things like water and soap, it’s not possible to practise hand hygiene”, and that the reviews confirmed this consistently.

Mills emphasises the importance of understanding behavioural drivers, describing the review on what shapes behaviour and the review on how those insights have been used to design interventions.

[“These reviews are] really interesting… they were just huge bits of work… for us to be able to draw conclusions from that was really valuable.”

“When you talk about how we might support countries to adopt and adapt the new guidelines, it’s really focusing on that role of government, which comes down to the policy environment, to legal and regulatory frameworks, to ensuring that there’s sufficient financing allocated, robust institutional arrangements, fit-for-purpose monitoring frameworks.”

This reflects how the guidelines frame hand hygiene as a government responsibility requiring coordinated policy, financing, and monitoring.

“Hand hygiene shouldn’t be thought of as a vertical programme of work… We can attach it to other relevant areas, whether it’s broader infection prevention and control programmes or broader programmes on school and child wellbeing.”

Joanna Esteves Mills
Global public health consultant and coordinator of the WHO’s guideline development process

Mills describes how WHO is integrating the guidance into existing commitments across water, health and education. She gives the example of the European Protocol on Water and Health, a legally binding agreement aimed at protecting human health and wellbeing, including through preventative interventions such as hand hygiene.

“By virtue of being at that [regional government meeting under the WHO European Region’s Protocol on Water and Health] meeting and presenting on the guidelines and having side meetings with governments, we’re able to shine a spotlight on the guidelines and on the evidence base that they come from, and encourage adoption that way.”

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